Eksplorasi Potensi Bioaktif dan Target Protein Isoflavanon Terprenilasi dari Erythrina poeppigiana dengan Pendekatan In Silico
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Abstract
Erythrina poeppigiana is a promising source of prenylated isoflavanones with diverse biological activities. This study aimed to evaluate the pharmacokinetic profiles and predict potential protein targets of Platyisoflavanone A, Erypogein D, and Sophoraisoflavanone A using SwissADME and SwissTargetPrediction. SwissADME analysis revealed that all compounds satisfied drug-likeness criteria, exhibited high gastrointestinal absorption, complied with Lipinski's rule of five, and showed a bioavailability score of 0.55. Protein target prediction identified Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) and Tyrosinase (TYR) as the major targets with the highest probability values for all compounds. Several additional targets associated with inflammation and cell proliferation, including ALOX5, ALOX12, ALOX15, PTGES, PTGS2, ESR1, FGFR1, KDR, and MET, were also predicted. These findings indicate that the three prenylated isoflavanones possess a multitarget pharmacological profile and may have potential as anti-inflammatory and antiproliferative agents. This study provides a preliminary scientific basis for further molecular docking studies and biological validation.
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